Respiratory Microbial Codetection and Clinical Profiles of Infants Living With HIV Hospitalized With Severe Pneumonia in Malawi

Pediatr Infect Dis J. 2025 Dec 1;44(12):e434-e436. doi: 10.1097/INF.0000000000004907. Epub 2025 Jun 20.

Abstract

Among the Malawian infants living with HIV and hospitalized with severe pneumonia, bacteria (87%), viruses (85%) and fungi (40%) were detected in the respiratory tract. All infants had polymicrobial codetection, and differences in respiratory microbial codetection groups were significantly associated with age and HIV viral load.

Keywords: HIV-infected infants; microbes; pneumonia.

MeSH terms

  • Bacteria / classification
  • Bacteria / isolation & purification
  • Coinfection* / epidemiology
  • Coinfection* / microbiology
  • Coinfection* / virology
  • Female
  • Fungi / classification
  • Fungi / isolation & purification
  • HIV Infections* / complications
  • HIV Infections* / epidemiology
  • HIV Infections* / microbiology
  • HIV Infections* / virology
  • Hospitalization
  • Humans
  • Infant
  • Malawi / epidemiology
  • Male
  • Pneumonia* / epidemiology
  • Pneumonia* / microbiology
  • Pneumonia* / virology
  • Viral Load
  • Viruses / classification
  • Viruses / isolation & purification