Effective community-engaged research is critical for designing and testing solutions to decrease the 10-year life expectancy gap between Black and non-Black residents of Chicago, Illinois. In community listening sessions, the Chicago Chronic Conditions Engagement Network found that community members' highest priority health issues were social determinants of health and that there is a strong mistrust of research. Conversations with leaders of community organizations addressing social determinants of health suggest strategies to help researchers overcome mistrust and build effective community-research partnerships. (Am J Public Health. 2025;115(S2):S130-S133. https://doi.org/10.2105/AJPH.2025.308082).