Familial granulomatous arthritis, iritis, and rash

J Pediatr. 1985 Nov;107(5):689-93. doi: 10.1016/s0022-3476(85)80394-2.


Eleven family members over four generations have had granulomatous disease of the skin, eyes, and joints. Ten have had arthritis; two had skin, eye, and joint involvement; one had skin and joint disease, and one had iritis only. The disease is transmitted as an autosomal dominant trait and is not associated with HLA-B27. The disease resembles sarcoidosis in some ways but not in others, and is probably a new syndrome. The major long-term problems are iritis and joint contractures.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Arthritis / genetics*
  • Child
  • Dermatitis / genetics*
  • Diagnosis, Differential
  • Female
  • Genes, Dominant*
  • Granulomatous Disease, Chronic / genetics*
  • Humans
  • Iritis / genetics*
  • Male
  • Pedigree
  • Sarcoidosis / diagnosis
  • Syndrome