Electron-Catalyzed Cross-Coupling Reaction of Arylzinc Reagents with Aryl Triflates Accelerated by Photoirradiation

Org Lett. 2025 Jul 11;27(27):7361-7366. doi: 10.1021/acs.orglett.5c02080. Epub 2025 Jun 27.

Abstract

The electron-catalyzed cross-coupling reaction of arylzinc reagents with aryl triflates was found to proceed under photoirradiation. Here arylzinc reagents undergo coupling with aryl triflates having an electron-donating or -withdrawing substituent. The studies on the reaction mechanism suggest that one of the driving forces of the carbon-carbon bond-forming step is a Lewis acid-base interaction between the metal center of arylzinc reagents and the leaving group of aryl electrophiles.