Induction of sister-chromatid exchanges in Chinese hamster ovary cells by the biotic ketoaldehyde methylglyoxal

Mutat Res. 1985 Nov;144(3):189-91. doi: 10.1016/0165-7992(85)90138-1.

Abstract

The number of sister-chromatid exchanges (SCEs) per metaphase was determined in Chinese hamster ovary cells after 16 h exposure to methylglyoxal (MG) concentrations ranging from 0.1 to 0.75 mM. MG produced an increase of SCE frequency that proved to be dose-dependent, and to reach a maximum of 2 X baseline at the highest nontoxic concentration (0.5 mM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / pharmacology*
  • Animals
  • Cell Line
  • Cricetinae
  • Cricetulus
  • Female
  • Ovary
  • Pyruvaldehyde / pharmacology*
  • Sister Chromatid Exchange / drug effects*

Substances

  • Aldehydes
  • Pyruvaldehyde