Deficits on conditional associative-learning tasks after frontal- and temporal-lobe lesions in man

Neuropsychologia. 1985;23(5):601-14. doi: 10.1016/0028-3932(85)90062-4.


Patients with unilateral frontal- or temporal-lobe excisions were tested on a spatial and a nonspatial conditional associative task. These tasks required the learning of arbitrary associations between a set of stimuli and a set of responses. Patients with excisions from the left or right frontal cortex were severely impaired in learning both tasks. Patients with left or right temporal-lobe excisions that did not involve extensive damage to the hippocampal region were not impaired, whilst those with more radical involvement of the hippocampal region exhibited deficits that were material-specific and varied with the side of the lesion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Association Learning* / physiology
  • Epilepsy / surgery
  • Female
  • Frontal Lobe / physiology
  • Frontal Lobe / surgery*
  • Humans
  • Learning Disabilities / etiology*
  • Learning*
  • Male
  • Middle Aged
  • Postoperative Complications / etiology
  • Spatial Behavior / physiology
  • Temporal Lobe / physiology
  • Temporal Lobe / surgery*