DDT supports the growth of an estrogen-responsive tumor

Toxicol Lett. 1985 Sep;27(1-3):109-13. doi: 10.1016/0378-4274(85)90127-4.


MT2 cells, a clonal cell line of MTW9/PL cells originally obtained from a mammary adenocarcinoma, from estrogen-responsive tumors in Wistar-Furth rats. o,p'-DDT supports MT2 tumor growth at a rate similar to 17 beta-estradiol. This effect of o,p'-DDT is dose-dependent and specific, since the DDT congener p,p'-DDD, which does not bind to tumor estrogen receptors, does not support tumor growth. This is the first demonstration that DDT can support the growth of an estrogen-responsive tumor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / pathology
  • Animals
  • DDT / toxicity*
  • Dose-Response Relationship, Drug
  • Estradiol / metabolism
  • Estrogens / pharmacology*
  • Female
  • Mammary Neoplasms, Experimental / pathology*
  • Neoplasms, Hormone-Dependent / pathology*
  • Rats
  • Rats, Inbred Strains


  • Estrogens
  • Estradiol
  • DDT