[Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives]

Vopr Pitan. Jul-Aug 1985;(4):51-4.
[Article in Russian]

Abstract

Study of the corticosteroid content in the adrenals and blood of rats under pantothenate deficiency has demonstrated a decrease in adrenocortical function. A single administration of pantothenate in a dose of 3.3 mg/kg reduced the influence of hypovitaminosis on the adrenals. The pantothenate derivatives (pantethine, 4'-phosphopantothenate and CoA in particular) injected to intact animals in a single dose equimolar to 3.3 mg/kg calcium pantothenate per kg bw had a marked steroidogenous effect.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • 11-Hydroxycorticosteroids / analysis
  • Adrenal Cortex / analysis
  • Adrenal Cortex / drug effects
  • Adrenal Cortex / physiopathology*
  • Animals
  • Coenzyme A / pharmacology
  • Male
  • Pantothenic Acid / analogs & derivatives
  • Pantothenic Acid / deficiency*
  • Pantothenic Acid / pharmacology
  • Rats
  • Restraint, Physical
  • Stress, Psychological / physiopathology

Substances

  • 11-Hydroxycorticosteroids
  • Pantothenic Acid
  • Coenzyme A