Cellular metabolite sensors: Arginine? It's in the bag!

Thomas D Jackson; Jonathan M Palozzi; Pere Puigserver

doi:10.1016/j.molcel.2025.06.010

Cellular metabolite sensors: Arginine? It's in the bag!

Mol Cell. 2025 Jul 3;85(13):2457-2459. doi: 10.1016/j.molcel.2025.06.010.

Authors

Thomas D Jackson¹, Jonathan M Palozzi¹, Pere Puigserver²

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
² Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address: pere_puigserver@dfci.harvard.edu.

PMID: 40614704
DOI: 10.1016/j.molcel.2025.06.010

Abstract

In this issue of Molecular Cell, Chen et al.¹ identify a novel arginine-sensing system, composed of the cytosolic proteins BAG2 and SAMD4B, which promotes cancer cell survival during arginine deficiency.

Publication types

Comment

MeSH terms

Animals
Arginine* / deficiency
Arginine* / metabolism
Cell Survival
Humans
Neoplasms* / metabolism
Neoplasms* / pathology

Substances

Arginine