From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP

Courtney M Cowan; Eric M Pietras

doi:10.1016/j.stem.2025.06.003

From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP

Cell Stem Cell. 2025 Jul 3;32(7):1036-1037. doi: 10.1016/j.stem.2025.06.003.

Authors

Courtney M Cowan¹, Eric M Pietras²

Affiliations

¹ Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
² Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Immunology & Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: eric.pietras@cuanschutz.edu.

PMID: 40614713
DOI: 10.1016/j.stem.2025.06.003

Abstract

Hematopoietic stem cells (HSCs) with mutations that can cause clonal hematopoiesis of indeterminate potential (CHIP) accumulate during aging. Agarwal et al.¹ demonstrate in Nature that intestinal barrier permeability increases with age and enables the microbial metabolite ADP-heptose to reach the bone marrow, thus driving the expansion of DNMT3A-mutant HSCs.

Published by Elsevier Inc.

MeSH terms

Animals
Clonal Hematopoiesis*
Gastrointestinal Microbiome*
Hematopoietic Stem Cells* / metabolism
Humans
Mice