Treatment of oligozoospermia with tamoxifen (open and controlled studies)

Andrologia. 1985 Sep-Oct;17(5):497-501. doi: 10.1111/j.1439-0272.1985.tb01048.x.


Open and double-blind therapeutic studies were carried out on the effects of tamoxifen in oligozoospermia. The examinations involved 74 patients. The first group (n = 20) received tamoxifen 20 mg/day; the second group (n = 54) got tamoxifen or placebo for 3 months. In the open study, tamoxifen treatment led to significant increases in the spermatozoa concentration and the total sperm count, but this could not be confirmed with the double-blind set-up.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Oligospermia / drug therapy*
  • Pregnancy
  • Sperm Count / drug effects
  • Sperm Motility / drug effects
  • Tamoxifen / therapeutic use*


  • Tamoxifen