Mitochondrial control of macrophage polarity in tumors

Máté Kiss; Mikael J Pittet

doi:10.1016/j.immuni.2025.06.008

Mitochondrial control of macrophage polarity in tumors

Immunity. 2025 Jul 8;58(7):1618-1620. doi: 10.1016/j.immuni.2025.06.008.

Authors

Máté Kiss¹, Mikael J Pittet²

Affiliations

¹ Department of Pathology and Immunology, and Center for Translational Oncohaematology Research, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland.
² Department of Pathology and Immunology, and Center for Translational Oncohaematology Research, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Ludwig Institute for Cancer Research, Lausanne, Switzerland; Department of Oncology, Geneva University Hospital, Geneva, Switzerland. Electronic address: mikael.pittet@unige.ch.

PMID: 40633525
DOI: 10.1016/j.immuni.2025.06.008

Abstract

Macrophages can foster pro- or anti-tumor immune environments. In this issue of Immunity, Clark et al. report that altering the composition of the mitochondrial electron transport chain reprograms macrophages toward a CXCL9^hiSPP1^lo immunostimulatory phenotype, thus amplifying anti-tumor immunity.

MeSH terms

Animals
Cell Polarity* / immunology
Humans
Macrophages* / immunology
Macrophages* / metabolism
Mice
Mitochondria* / immunology
Mitochondria* / metabolism
Neoplasms* / immunology
Neoplasms* / metabolism
Tumor Microenvironment / immunology