Myoclonus, hyperreflexia and diaphoresis in patients on phenelzine-tryptophan combination treatment

Can J Psychiatry. 1985 Oct;30(6):434-6. doi: 10.1177/070674378503000612.

Abstract

Three cases are presented on patients on an MAOI who developed a transient syndrome of myoclonus, hyperreflexia, jaw quivering, teeth chattering and diaphoresis after L-Tryptophan was added. Caution is advised when considering the addition of a serotonergic agent to MAOI's.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antidepressive Agents, Tricyclic / adverse effects
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hyperhidrosis / chemically induced*
  • Male
  • Middle Aged
  • Monoamine Oxidase Inhibitors / adverse effects
  • Myoclonus / chemically induced*
  • Phenelzine / adverse effects*
  • Reflex, Abnormal / chemically induced*
  • Syndrome
  • Tryptophan / adverse effects*

Substances

  • Antidepressive Agents, Tricyclic
  • Monoamine Oxidase Inhibitors
  • Tryptophan
  • Phenelzine