Sotos syndrome--autosomal dominant inheritance substantiated

Clin Genet. 1985 Sep;28(3):243-6. doi: 10.1111/j.1399-0004.1985.tb00393.x.


Sotos syndrome, or Cerebral Gigantism is recognised as the syndromic association of mental retardation, macrocephaly and prenatal onset of accelerated growth. A kindred has been investigated in which the father and 4 affected offspring all have the Sotos syndrome. Autosomal dominant inheritance has been postulated in the past, and the family conform to this genetic pattern.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Genes, Dominant
  • Gigantism / genetics*
  • Humans
  • Intellectual Disability / genetics
  • Male
  • Pedigree
  • Syndrome