Rickets and osteopetrosis: the osteosclerotic (oc) mouse

Clin Orthop Relat Res. 1985 Dec;(201):238-46.


A new mouse osteopetrotic mutation, osteosclerosis, has been examined with respect to rickets. These osteopetrotic mice were hypocalcemic and hypophosphatemic, and had greatly thickened epiphyseal plates with abnormalities in matrix vesicles when compared with normal littermates. Such biochemic and morphologic manifestations of rickets in this osteopetrotic mutation may explain the failure of osteosclerotic mice to be cured by transplantation of bone marrow from normal littermates and indicate that vitamin D metabolism and matrix vesicle biochemistry warrant further study.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium / blood
  • Growth Plate / ultrastructure*
  • Mice
  • Mice, Inbred Strains
  • Microscopy, Electron
  • Osteopetrosis / metabolism
  • Osteopetrosis / pathology*
  • Osteosclerosis / metabolism
  • Osteosclerosis / pathology*
  • Phosphorus / blood
  • Rickets / metabolism
  • Rickets / pathology*


  • Phosphorus
  • Calcium