Quick fixes, lasting problems: Rethinking obesity management through a public health lens beyond pharmacological solutions

Nutr Metab Cardiovasc Dis. 2025 Dec;35(12):104205. doi: 10.1016/j.numecd.2025.104205. Epub 2025 Jun 21.

Abstract

Aim: This viewpoint aims to critically examine the growing reliance on pharmacological treatments for obesity and highlight the limitations of such an approach.

Data synthesis: Literature from reputable databases and public health registries were sought and used to formulate an evidence-based viewpoint, critically synthesizing current research on obesity pharmacotherapy and its implications within a broader socio-environmental context.

Conclusions: In response to the obesity epidemic, pharmacological treatments have gained significant attention for their ability to produce substantial weight loss in the short-term. However, the increasing reliance on these medication risks narrowing the understanding, prevention and management of obesity to a purely clinical issue, overlooking its deeper individual-level and societal causes. While pharmacological interventions may offer short-term benefits, they do not address the root causes of obesity, such as the socio-environmental drivers influencing food choices with over-reliance on high-calorie and processed foods, sedentary lifestyles, and socio-economic disparities. Additionally, the high cost of these treatments exacerbates health inequities, limiting access for vulnerable populations. Obesity must be approached as a complex, multifaceted condition, requiring multisectoral approaches as well as integrated care models that combine pharmacological treatments with behavioural interventions, lifestyle modifications, and systemic policy changes. Population-wide strategies are crucial for long-term prevention. This viewpoint argues for comprehensive, multisectoral approaches to obesity prevention and management that moves beyond pharmacological solutions to address the broader socio-environmental factors contributing to the obesity epidemic. Only through systemic changes can we expect to improve public health outcomes and reduce the global burden of obesity.

Keywords: Health equity; Medicalization; Obesity; Obesity prevention; Public health; Socio-environmental factors.

MeSH terms

  • Anti-Obesity Agents* / adverse effects
  • Anti-Obesity Agents* / therapeutic use
  • Healthcare Disparities
  • Humans
  • Obesity* / diagnosis
  • Obesity* / drug therapy
  • Obesity* / economics
  • Obesity* / epidemiology
  • Obesity* / physiopathology
  • Obesity* / therapy
  • Public Health*
  • Risk Factors
  • Risk Reduction Behavior
  • Treatment Outcome
  • Weight Loss* / drug effects

Substances

  • Anti-Obesity Agents