Neuro-immune crosstalk: focus on innate lymphoid cells

John W Bostick; Liang Zhou

doi:10.1016/j.it.2025.06.005

Neuro-immune crosstalk: focus on innate lymphoid cells

Trends Immunol. 2025 Aug;46(8):559-561. doi: 10.1016/j.it.2025.06.005. Epub 2025 Jul 11.

Authors

John W Bostick¹, Liang Zhou²

Affiliations

¹ Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
² Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA; Center for Inflammation and Mucosal Immunology, University of Florida, Gainesville, FL 32608, USA. Electronic address: liangzhou497@ufl.edu.

PMID: 40651882
PMCID: PMC12258959 (available on 2026-07-11)
DOI: 10.1016/j.it.2025.06.005

Abstract

Neuro-immune crosstalk regulates inflammation and host metabolism via neural modulation of innate lymphoid cells (ILCs). Significant knowledge gaps remain regarding the signaling pathways, regulators, and physiological relevance of these interactions in human health and disease. Future studies leveraging innovative tools promise new insights and therapies for inflammatory and metabolic diseases.

Keywords: inflammation and metabolism; innate lymphoid cells (ILCs); neuro–immune crosstalk; sensory neurons; sonogenetics.

Publication types

Review

MeSH terms

Animals
Humans
Immunity, Innate*
Inflammation / immunology
Lymphocytes* / immunology
Lymphocytes* / metabolism
Neuroimmunomodulation*
Signal Transduction

Abstract

Publication types

MeSH terms

Grants and funding