Comparison of the effects of different isomers of bicuculline infused in the preoptic area on male rat sexual behavior

Experientia. 1985 Nov 15;41(11):1414-6. doi: 10.1007/BF01950011.


Intracerebral infusion of (+) bicuculline methiodide, but not of its (-) isomer, in the preoptic area, stimulated masculine sexual behavior in rat as evidenced by a decrease in the number of intromissions preceding ejaculation and a shortening of the ejaculation latency and postejaculatory interval. Data suggest a role of the GABAergic system in mediating masculine sexual behavior.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bicuculline / administration & dosage
  • Bicuculline / analogs & derivatives*
  • Bicuculline / pharmacology
  • Ejaculation
  • Isomerism
  • Male
  • Preoptic Area / drug effects
  • Preoptic Area / physiology*
  • Rats
  • Rats, Inbred Strains
  • Sexual Behavior, Animal / drug effects*
  • Time Factors


  • bicuculline methiodide
  • Bicuculline