Clinicopathologic studies on neuro-Behçet's disease

Folia Psychiatr Neurol Jpn. 1985;39(2):155-66. doi: 10.1111/j.1440-1819.1985.tb02899.x.


Nine cases of neuro-Behcet's disease were investigated clinicopathologically. Pathological pictures of the central nervous system were characterized as follows: the site of predilection was the brain stem, followed by the spinal cord, cerebrum and cerebellum. The pathognomonic changes were recurrent inflammations around small vessels, causing a softening of the tissue. Lesions were composed of a perivascular infiltration of lymphocytes, histiocytes and microglias and, moreover, diapedesis, degenerated nerve cells and oligodendroglias, glial nodule, breakdown of myelin and axon, fatty granule cells and glio-mesenchymal proliferation were present occasionally. Electron microscopic studies on the neurons revealed no evidence of viral particles except for some accumulations of electron dense bodies.

MeSH terms

  • Adult
  • Behcet Syndrome / complications
  • Behcet Syndrome / pathology*
  • Brain Stem / pathology
  • Central Nervous System / pathology*
  • Cerebellum / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nervous System Diseases / complications*
  • Nervous System Diseases / pathology
  • Spinal Cord / pathology