Preparation of 13N-beta-phenethylamine

Int J Appl Radiat Isot. 1985 Jul;36(7):555-60. doi: 10.1016/0020-708x(85)90109-7.


Nitrogen-13-labelled beta-phenethylamine[( 13N]PEA) was synthesized by Hofmann rearrangement of [13N]phenylpropionamide prepared from phenylpropionyl chloride and aqueous [13N]ammonia solution. The reaction proceeded rapidly with a fairly good yield. [13N]PEA was isolated using preparative thin-layer chromatography, and organ distribution in mice was studied preliminarily. After i.v. administration of [13N]PEA, high accumulation and long-term retention of the radioactivity were observed in the brain and the heart.

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Isotope Labeling / methods
  • Male
  • Mice
  • Mice, Inbred Strains
  • Nitrogen Radioisotopes
  • Phenethylamines / chemical synthesis*
  • Phenethylamines / isolation & purification
  • Phenethylamines / metabolism
  • Tissue Distribution


  • Nitrogen Radioisotopes
  • Phenethylamines
  • phenethylamine