Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics

Int J Toxicol. 2025 Aug;44(2_suppl):54S-63S. doi: 10.1177/10915818251340391. Epub 2025 Jul 17.

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Acetyl Hexapeptide-8 Amide (synonymous with Acetyl Hexapeptide-8 (sans "Amide")) in cosmetic products; this ingredient is reported to function as a skin conditioning agent - miscellaneous in cosmetics. The Panel reviewed data relevant to the safety of this ingredient in cosmetic formulations, and concluded that Acetyl Hexapeptide-8 Amide is safe in cosmetics in the present practices of use at concentrations up to 0.005%. The Panel further concluded that the available data are insufficient to make a determination that Acetyl Hexapeptide-8 Amide is safe under the intended conditions of use in cosmetic formulations at concentrations greater than 0.005%.

Keywords: Acetyl Hexapeptide-8; Acetyl Hexapeptide-8 Amide; Cosmetic Ingredient Review; Cosmetics; Expert Panel for Cosmetic Ingredient Safety; Ingredients; Safety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Consumer Product Safety
  • Cosmetics* / chemistry
  • Cosmetics* / toxicity
  • Humans
  • Oligopeptides* / chemistry
  • Oligopeptides* / pharmacokinetics
  • Oligopeptides* / toxicity
  • Risk Assessment
  • Toxicity Tests

Substances

  • Cosmetics
  • Oligopeptides