Hepatotoxicity induced by MK-677

BMJ Case Rep. 2025 Jul 17;18(7):e265728. doi: 10.1136/bcr-2025-265728.

Abstract

MK-677, a growth hormone secretagogue, is gaining popularity among performance-enhancing supplements. While its side effects include oedema, increased appetite and muscle pain, reports of hepatotoxicity are scarce. Here we present the case of an otherwise healthy man in his early 30s, who developed transaminitis after consuming MK-677 for 2 months before presentation. Liver function tests eventually returned to normal limits after stopping the supplement.

Keywords: General practice / family medicine; Liver disease; Nutrition; Vitamins and supplements.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chemical and Drug Induced Liver Injury* / diagnosis
  • Chemical and Drug Induced Liver Injury* / etiology
  • Dietary Supplements* / adverse effects
  • Humans
  • Liver Function Tests
  • Male