Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal

Danielle R Bond; Sean M Burnard; Kumar Uddipto; Kooper V Hunt; Brooke M Harvey; Luiza Steffens Reinhardt; Charley Lawlor-O'Neill; Ellise A Roper; Sam Humphries; Heather C Murray; Abdul Mannan; Matthew D Dun; Charles E de Bock; Nikola A Bowden; Anoop K Enjeti; Nicole M Verrills; Carlos Riveros; Kim-Anh Lê Cao; Heather J Lee

doi:10.1038/s41375-025-02693-5

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal

Leukemia. 2025 Sep;39(9):2275-2280. doi: 10.1038/s41375-025-02693-5. Epub 2025 Jul 17.

Authors

Danielle R Bond^#^{1

2}, Sean M Burnard^#^{3

4}, Kumar Uddipto^{3

4}, Kooper V Hunt^{3

4}, Brooke M Harvey^{3

4}, Luiza Steffens Reinhardt^{3

5

6}, Charley Lawlor-O'Neill³, Ellise A Roper³, Sam Humphries^{3

4}, Heather C Murray^{3

4}, Abdul Mannan^{3

4}, Matthew D Dun^{3

4}, Charles E de Bock^{7

8}, Nikola A Bowden^{9

10}, Anoop K Enjeti^{4

6

9

11}, Nicole M Verrills^{3

4}, Carlos Riveros⁹, Kim-Anh Lê Cao¹², Heather J Lee^{13

14}

Affiliations

¹ School of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia. danielle.bond@newcastle.edu.au.
² Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. danielle.bond@newcastle.edu.au.
³ School of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
⁴ Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
⁵ Cancer Detection and Therapy Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
⁶ New South Wales Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia.
⁷ Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, NSW, Australia.
⁸ School of Clinical Medicine, Faculty of Medicine, UNSW, Randwick, NSW, Australia.
⁹ School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.
¹⁰ Drug Repurposing and Medicines Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
¹¹ Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia.
¹² Melbourne Integrative Genomics, School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, Australia.
¹³ School of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia. Heather.lee@newcastle.edu.au.
¹⁴ Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. Heather.lee@newcastle.edu.au.

^# Contributed equally.

No abstract available

Grants and funding