Time Course of Electrocortical Processing of Food Stimuli in Adolescent Anorexia Nervosa

Int J Eat Disord. 2025 Oct;58(10):1979-1990. doi: 10.1002/eat.24510. Epub 2025 Jul 18.

Abstract

Objective: Anorexia nervosa (AN) typically manifests during adolescence and is linked to significant psychological and physical sequelae. A better understanding of the underlying maintenance mechanisms of adolescent AN is therefore crucial. Cognitive behavioral theories emphasize the influence of cognitive biases in the processing of disorder-relevant stimuli.

Method: The current study investigated attentional bias to high- and low-calorie food in female adolescents with AN (n = 31) and without AN (n = 35). An event-related potentials study utilizing prolonged stimulus presentation in an attention task was conducted.

Results: Against our hypotheses, the results suggest an early avoidance of (i.e., reduced early posterior negativity) and an increased motivated attention (i.e., enhanced P300) towards high-calorie food in females with AN relative to controls.

Discussion: The automated early avoidance indicates a decline in the positive incentive value of high-calorie food, which signals a loss of the appetitive character of these foods. The increased top-down attention towards food may be due to an increased negative emotional salience activating aversive motivational systems.

Keywords: adolescence; anorexia nervosa; attentional bias; event‐related potential; food stimuli; psychophysiology.

MeSH terms

  • Adolescent
  • Anorexia Nervosa* / physiopathology
  • Anorexia Nervosa* / psychology
  • Attention* / physiology
  • Attentional Bias* / physiology
  • Electroencephalography
  • Evoked Potentials* / physiology
  • Female
  • Food*
  • Humans
  • Motivation / physiology