Hepatic focal nodular hyperplasia after liver transplantation: case report and review of literature

Clin J Gastroenterol. 2025 Oct;18(5):910-917. doi: 10.1007/s12328-025-02180-5. Epub 2025 Jul 18.

Abstract

Patients with decompensated cirrhosis complicated by hepatocellular carcinoma (HCC) or those who have undergone liver transplantation following liver failure after HCC treatment should continue to receive post-transplant surveillance. Any new liver tumor must be carefully evaluated to determine whether it is a recurrence of HCC. Focal nodular hyperplasia (FNH), the second most common benign hepatic tumor, is believed to result from the hyperplastic response of hepatocytes to pre-existing vascular malformation. Here, we report a case of hepatic FNH two years after living-donor liver transplantation in a patient who experienced liver failure following treatment for HCC. Given the rarity of hepatic FNH after liver transplantation, we present this case along with a review of the literature.

Keywords: Focal nodular; Hepatocellular carcinoma; Hyperplasia; Liver transplantation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Carcinoma, Hepatocellular / surgery
  • Focal Nodular Hyperplasia* / diagnostic imaging
  • Focal Nodular Hyperplasia* / etiology
  • Focal Nodular Hyperplasia* / pathology
  • Humans
  • Liver Neoplasms / surgery
  • Liver Transplantation* / adverse effects
  • Male
  • Middle Aged
  • Postoperative Complications*