Trop2 is overexpressed in various tumors and serves as a key biomarker. Targeted immunoPET ligands, mainly developed from Trop2 monoclonal antibodies and nanobodies, provide the landscape of heterogeneous expression of Trop2 in tumors, which has great potential in improving accuracy of cancer diagnosis and staging, as well as decision-making in therapy.
Keywords: Trophoblast cell-surface antigen 2 (Trop2); immunoPET ligand; in vivo imaging; nanobody; tumor.
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