Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 318 (6043), 257-63

Transposition of Structural Genes to an Expression Sequence on a Linear Plasmid Causes Antigenic Variation in the Bacterium Borrelia Hermsii

Transposition of Structural Genes to an Expression Sequence on a Linear Plasmid Causes Antigenic Variation in the Bacterium Borrelia Hermsii

R H Plasterk et al. Nature.

Abstract

In Borrelia hermsii, a spirochaete that causes relapsing fever, the switch between expression of two frequent variable major protein (VMP) types (7 and 21) is associated with a DNA rearrangement. Both cell types 7 and 21 contain untranscribed 7 and 21 VMP genes on linear plasmids. The serotype 7 cells contain an additional copy of the 7 VMP gene fused to an expression sequence on another linear plasmid. Switching to the 21 serotype involves removal of the transcribed 7 VMP gene and fusion of a copy of the 21 VMP gene to this same expression sequence. Thus recombination between linear plasmids can activate different VMP genes.

Similar articles

See all similar articles

Cited by 99 PubMed Central articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback