Abstract
Looking for receptor correlates of increased motor response to dopaminergic stimulation in rats after antidepressant treatments, we measured specific 3H-spiroperidol binding to membranes from various brain ureas in rats receiving chronically electroconvulsive shock (ECS), imipramine or trazodone. In all groups the low-affinity 3H-spiroperidol binding (KD approximately 3 nM) was increased in the cortex, but not in the subcortical areas.
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Butyrophenones / metabolism*
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Cerebral Cortex / drug effects*
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Cerebral Cortex / metabolism
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Electroconvulsive Therapy
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Imipramine / pharmacology
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Kinetics
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Male
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / metabolism
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Spiperone / metabolism*
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Trazodone / pharmacology
Substances
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Antidepressive Agents
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Butyrophenones
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Receptors, Dopamine
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spiroperidol receptor
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Spiperone
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Imipramine
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Trazodone