Oxygen-ozone adjunct therapy in aging and senescence-related disorders. State of art

Adv Pharmacol. 2025:104:417-446. doi: 10.1016/bs.apha.2025.03.001. Epub 2025 Apr 15.

Abstract

Ozone therapy presents as a promising yet controversial approach to anti-aging and health rejuvenation, due to an ongoing and crucially debated need for standardization about protocols, procedures, and dosages. While it offers potential benefits in improving skin health, boosting energy levels, and reducing inflammation, its use must be carefully considered only by specialized, highly trained experts and professionals, due to potential risks related to malpractice and shallow or clumsy fashion trends. The ability of ozone to address senescent mechanisms and aging-related processes makes this adjunct therapy a promising approach for aging-related impairments, such as neurodegenerative disorders and cardiovascular pathologies.

Keywords: Aging; Chaos; Complexity; Fractality; Ozone; Senescence; Therapy.

Publication types

  • Review

MeSH terms

  • Aging* / drug effects
  • Animals
  • Humans
  • Neurodegenerative Diseases* / drug therapy
  • Oxygen* / therapeutic use
  • Ozone* / pharmacology
  • Ozone* / therapeutic use

Substances

  • Ozone
  • Oxygen