Blueberries and Their Polyphenols: A Review of the Evidence and the Potential Impact on Inflammation, Oxidative Stress, Vascular and Cardiometabolic Function

Shivangi Sharma

doi:10.2174/0115734064300135250707043513

Blueberries and Their Polyphenols: A Review of the Evidence and the Potential Impact on Inflammation, Oxidative Stress, Vascular and Cardiometabolic Function

Med Chem. 2025 Jul 24. doi: 10.2174/0115734064300135250707043513. Online ahead of print.

Author

Shivangi Sharma¹

Affiliation

¹ Department of Applied Chemistry, Amity School of Applied Sciences, Amity University Madhya Pradesh, Maharajpura Dang, Gwalior, 474 005, India.

PMID: 40734444
DOI: 10.2174/0115734064300135250707043513

Abstract

Blueberries contain a wide range of bioactive compounds, including polyphenols- plant-based chemicals known for their antioxidant and anti-inflammatory properties. Numerous in vitro and animal studies have suggested that these compounds may promote health. However, evidence regarding the effects of blueberries and their bioactive components in humans remains limited. This review focuses on 45 human studies investigating how blueberry consumption may influence markers of inflammation, oxidative stress, vascular function, cardiovascular health, and metabolic outcomes in both healthy and at-risk individuals. While some findings suggest potential benefits, especially for vascular function, more high-quality, well-controlled human trials are needed to confirm these effects. Furthermore, research exploring the relationship between the structure of specific polyphenols and their biological activity is essential for a deeper understanding of the mechanisms behind the reported health benefits.

Keywords: Blueberry; atherosclerosis.; biomarkers; crossover; diseases; double blind; gut microbiota; oxidative stress.