Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: 5-Year Follow-Up of a Randomized Clinical Trial

Yoni K Ashar; Ethan L Low; Karen Knight; Howard Schubiner; Alan Gordon; Andrew LeRoux; Mark A Lumley; Tor D Wager

doi:10.1001/jamapsychiatry.2025.1844

Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: 5-Year Follow-Up of a Randomized Clinical Trial

JAMA Psychiatry. 2025 Oct 1;82(10):1049-1051. doi: 10.1001/jamapsychiatry.2025.1844.

Authors

Yoni K Ashar¹, Ethan L Low^{1

2}, Karen Knight³, Howard Schubiner^{4

5}, Alan Gordon⁶, Andrew LeRoux¹, Mark A Lumley⁷, Tor D Wager⁸

Affiliations

¹ Division of Internal Medicine, University of Colorado Anschutz Medical Campus, Denver.
² Baylor College of Medicine, Houston, Texas.
³ Panorama Orthopedics and Spine Center, Golden, Colorado.
⁴ Michigan State University College of Human Medicine, Pleasant Ridge.
⁵ Cormendi Health, Chicago, Illinois.
⁶ Pain Psychology Center, Los Angeles, California.
⁷ Department of Psychology, Wayne State University, Detroit, Michigan.
⁸ Department of Brain and Psychological Sciences, Dartmouth College, Hanover, New Hampshire.

PMID: 40736996
PMCID: PMC12311821 (available on 2026-07-30)
DOI: 10.1001/jamapsychiatry.2025.1844

No abstract available

Plain language summary

This secondary analysis of a randomized clinical trial provided 5-year follow-up data for individuals with chronic back pain treated with pain reprocessing therapy, placebo, or usual care.