Translational traffic jam in aging brains

Science. 2025 Jul 31;389(6759):457-458. doi: 10.1126/science.adz4995. Epub 2025 Jul 31.

Authors

Olivier Dionne¹, Benoit Laurent^{1

2}

Affiliations

¹ Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
² Research Center on Aging, Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.

PMID: 40743358
DOI: 10.1126/science.adz4995

Abstract

Ribosome stalling drives aging in the killifish brain.

Publication types

Comment

MeSH terms

Aging* / genetics
Aging* / metabolism
Animals
Brain* / metabolism
Killifishes* / growth & development
Killifishes* / metabolism
Peptide Chain Elongation, Translational
Proteostasis*
Ribosomes* / metabolism