This study investigated the effect of two types of exercise on the hypothalamic expression of CRH and GnRH genes in response to acute noise stress in young rats. 42 male Wistar rats were divided into 7 groups including control (Con), Control Time (CT), acute noise stress (S), Moderate-intensity Continuous Training (MCT), High-Intensity Interval Training (HIIT), MCT + noise stress (MS), and HIIT + noise stress (HS). Exercise raining was performed for eight weeks. Noise stress was induced for one session. Hippocampus samples were taken 48 h following eight weeks in exercise training groups (MCT and HIIT) as well as CT and just after noise stress in related groups (S, HS, and MS). One-way analysis of variance (ANOVA) was used to compare the groups. CRH expression was significantly higher in the HIIT group while was significantly lower in the MCT group compared to the CT group (P = 0.0001). GnRH expression was significantly lower in the HIIT group than the MCT group; it was significantly higher in MCT group than the CT group (P = 0.0001). CRH expression increased in S group (P = 0.0001); it was significantly lower in HS and MS groups than in S group. CRH expression was significantly higher while, GnRH expression was significantly lower in the MS group compared to MCT group (P = 0.0001). So, HIIT inhibited GnRH and increased CRH while MCT increased GnRH and inhibited CRH gene expression. HIIT and MCT training, in that order, were effective in reducing the effects of noise stress.
Keywords: Acute noise stress; CRH; Corticosterone; Exercise training; GnRH; Intensity.
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