Excretion of doxepin and N-desmethyldoxepin in human milk

Br J Clin Pharmacol. 1985 Nov;20(5):497-9. doi: 10.1111/j.1365-2125.1985.tb05106.x.

Abstract

Doxepin and N-desmethyldoxepin concentrations in plasma and breast milk from a lactating mother and in plasma from her infant were measured during an 8 week period using high performance liquid chromatography. Plasma concentrations ranged from 35-68 microgram l-1 for doxepin and 65-131 microgram l-1 for N-desmethyldoxepin. Mean pre-feed milk/plasma ratios were 1.08 and 1.02 for doxepin and N-desmethyldoxepin respectively and increased to 1.66 and 1.53 at the post-feed samples. Only N-desmethyldoxepin (15 microgram l-1) was detectable in the infant's plasma sampled after 43 days of maternal therapy.

MeSH terms

  • Adult
  • Breast Feeding
  • Depressive Disorder / drug therapy
  • Doxepin / analogs & derivatives*
  • Doxepin / blood
  • Doxepin / metabolism*
  • Female
  • Humans
  • Infant
  • Milk, Human / metabolism*

Substances

  • Doxepin
  • desmethyldoxepin