Handheld 400kHz optical coherence tomography angiography visualizes microvascular details in infants with advanced retinopathy of prematurity

Amit Narawane; Christian Viehland; Ryan Imperio; Du Tran-Viet; Shwetha Mangalesh; Joseph A Izatt; Xi Chen; Cynthia A Toth

doi:10.1016/j.ajoc.2025.102401

Handheld 400kHz optical coherence tomography angiography visualizes microvascular details in infants with advanced retinopathy of prematurity

Am J Ophthalmol Case Rep. 2025 Jul 23:39:102401. doi: 10.1016/j.ajoc.2025.102401. eCollection 2025 Sep.

Authors

Amit Narawane¹, Christian Viehland¹, Ryan Imperio², Du Tran-Viet², Shwetha Mangalesh², Joseph A Izatt^{1

2}, Xi Chen², Cynthia A Toth^{2

1}

Affiliations

¹ Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
² Department of Ophthalmology, Duke University, Durham, NC, 27708, USA.

Abstract

Clinical evaluation of the disease activity of retinopathy of prematurity (ROP) is routinely performed via indirect ophthalmoscopy and/or widefield fundus photography. Herein we report an infant with advanced ROP imaged with an investigational handheld 400kHz optical coherence tomography angiography system that visualized microvascular details not seen in fundus exam or photography.