Probabilistic Mapping of Magnetic Resonance-Guided Focused Ultrasound (MRgFUS) Thalamotomy Targets in Essential Tremor and Tremor-Dominant Parkinson's Disease: Insights from a German Cohort

Mov Disord. 2025 Nov;40(11):2540-2542. doi: 10.1002/mds.70003. Epub 2025 Aug 8.

Abstract

Precise targeting in magnetic resonance-guided focused ultrasound (MRgFUS) is critical for effective tremor control in essential tremor and tremor-dominant Parkinson's disease, as small deviations can reduce efficacy or cause side effects. In our cohort, sweetspots were identified at Montreal Neurological Institute (MNI) coordinates x = -12.4, y = -17.5, z = -1.7 (ET) and x = -13.4, y = -19.8, z = -3.0 (TDPD).

Publication types

  • Letter

MeSH terms

  • Aged
  • Cohort Studies
  • Essential Tremor* / diagnostic imaging
  • Essential Tremor* / surgery
  • Female
  • Germany
  • Humans
  • Magnetic Resonance Imaging* / methods
  • Male
  • Middle Aged
  • Parkinson Disease* / diagnostic imaging
  • Parkinson Disease* / surgery
  • Thalamus* / diagnostic imaging
  • Thalamus* / surgery
  • Tremor* / surgery