A 675 nm laser for lip augmentation and perioral rejuvenation treatment

Photodiagnosis Photodyn Ther. 2025 Oct:55:104760. doi: 10.1016/j.pdpdt.2025.104760. Epub 2025 Aug 9.

Abstract

Background: Injectable lip augmentation products are one of the most common treatments in aesthetic medicine. The literature indicates that there are innovative needle-free strategies for lip rejuvenation.

Aim: This retrospective study explores the application of a 675 nm-emitting device for improving lip volume and defining lip contour.

Methods: A total of 24 patients were treated for lip rejuvenation with the device emitting red light with a wavelength of 675 nm. For each patient, a total of one or two sessions were conducted at intervals of 1 month. At baseline and for the first three months from follow-up, standardized pictures were collected. A 5-point Global Aesthetic Improvement Scale (GAIS) and a Visual Analogue Scale (VAS) were used.

Results: Mean VAS results confirmed that the treatment was almost painless (mean value 1.25±0.5) for the patients. The GAIS demonstrated moderate to good overall improvement in the clinical results (mean value 2.5 ± 0.6) after the treatment. Specifically, considering different levels of improvement such as lip volume, colour, and texture, the results were 2.25 ± 0.5, 2.5 ± 0.6, and 2.5 ± 0.6, respectively. The upper lip ratio resulted in an augmentation of 118 ± 11 %, while the lower lip ratio results in an augmentation of 109 ± 5 %. Clinical measurement revealed that the ratio between the lower and upper lips (b/a) results were 1.45 ±0.31 before, and 1.32 ±0.2 after the treatment, respectively.

Conclusions: 675 nm laser in women demonstrated to be a safe, easy, quick and pain-free solution with good results and great patient satisfaction for lip augmentation and perioral rejuvenation.

Keywords: 675 nm laser; Collagen; Lip augmentation; Lip rejuvenation.

MeSH terms

  • Adult
  • Cosmetic Techniques*
  • Female
  • Humans
  • Lip* / radiation effects
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Photochemotherapy* / methods
  • Rejuvenation*
  • Retrospective Studies