The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity

Nature. 1985 Dec 19-1986 Jan 1;318(6047):630-5. doi: 10.1038/318630a0.


Plasmid expression vectors carrying either the entire engrailed coding region or a subfragment including the homoeo box, produce protein fusions having sequence-specific DNA binding activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • DNA / analysis*
  • DNA / metabolism
  • Drosophila / genetics
  • Electrophoresis, Polyacrylamide Gel
  • Plasmids
  • Structure-Activity Relationship


  • DNA