Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies

Ningxuan Wang; Xiangan Li; Chenyang She; Jun Zhang

doi:10.1186/s12935-025-03941-5

Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies

Cancer Cell Int. 2025 Aug 14;25(1):304. doi: 10.1186/s12935-025-03941-5.

Authors

Ningxuan Wang¹, Xiangan Li¹, Chenyang She¹, Jun Zhang²

Affiliations

¹ College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.
² College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China. zhj@shnu.edu.cn.

Abstract

Leukemia is a malignant clonal disease originating from hematopoietic stem cells. Its pathogenesis is associated with multiple factors, including biological, physical, chemical, genetic, and other hematological diseases. Previous studies have shown that a high mutation rate (>80%) of colony-stimulating factor receptor 3 (CSF3R) is observed in chronic neutrophilic leukemia (CNL) patients, and these mutations activate downstream signaling pathways, leading to the proliferation of neutrophils. In-depth research on the CSF3R genes and their related mechanisms will help further reveal the mechanisms of leukemia development and provide potential targets for treatment. Therefore, this paper mainly focuses on the roles of colony-stimulating factor 3 (CSF3R) in hematopoiesis and the occurrence of leukemia, with particular attention to the roles of CSF3R in the JAK-STAT, PI3K-AKT, and MAPK-ERK signaling pathways.

Keywords: CSF3R; Hematopoiesis; Leukemia; Mutation; Signaling pathway.

Publication types

Review

Grants and funding

No.32171100/National Natural Science Foundation of China