Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with refractory systemic lupus erythematosus - Authors' reply

Melanie Hagen; Fabian Müller; Andreas Wirsching; Soraya Kharboutli; Silvia Spoerl; Christina Düsing; Tobias Krickau; Markus Metzler; Simon Völkl; Michael Aigner; Sascha Kretschmann; Ingrid Vasova; Marc Saake; Stefan Schliep; Torsten Kubacki; Nicolas Hunzelmann; Laura Bucci; Jule Taubmann; Christina Bergmann; Andrea-Hermina Györfi; Sascha Dietrich; Jörg H W Distler; Ricardo Grieshaber-Bouyer; Andreas Mackensen; Georg Schett

doi:10.1016/S2665-9913(25)00222-X

Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with refractory systemic lupus erythematosus - Authors' reply

Lancet Rheumatol. 2025 Oct;7(10):e667-e669. doi: 10.1016/S2665-9913(25)00222-X. Epub 2025 Aug 12.

Authors

Melanie Hagen¹, Fabian Müller², Andreas Wirsching¹, Soraya Kharboutli², Silvia Spoerl², Christina Düsing³, Tobias Krickau⁴, Markus Metzler⁴, Simon Völkl², Michael Aigner², Sascha Kretschmann², Ingrid Vasova², Marc Saake⁵, Stefan Schliep⁶, Torsten Kubacki⁷, Nicolas Hunzelmann⁸, Laura Bucci¹, Jule Taubmann¹, Christina Bergmann¹, Andrea-Hermina Györfi³, Sascha Dietrich⁹, Jörg H W Distler³, Ricardo Grieshaber-Bouyer¹, Andreas Mackensen², Georg Schett¹⁰

Affiliations

¹ Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
² Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany; Department of Internal Medicine 5 - Hematology and Oncology, FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
³ Department of Rheumatology, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University Duesseldorf, Duesseldorf, Germany; Hiller Research Center, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University Duesseldorf, Duesseldorf, Germany.
⁴ Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany; Department of Pediatrics and Adolescent Medicine, FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
⁵ Department of Radiology, FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
⁶ Department of Dermatology, FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
⁷ Department of Nephrology and Rheumatology, University and University Hospital Cologne, Cologne, Germany.
⁸ Department of Dermatology, University and University Hospital Cologne, Cologne, Germany.
⁹ Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich Heine University Duesseldorf, Duesseldorf, Germany.
¹⁰ Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address: georg.schett@uk-erlangen.de.

PMID: 40816306
DOI: 10.1016/S2665-9913(25)00222-X

No abstract available

Publication types

Letter