Mathematical model of pituitary thyrotropic function

Experientia. 1977 Sep 15;33(9):1243-5. doi: 10.1007/BF01922356.

Abstract

A nonlinear differential equation is used to develop a mathematical model describing the time course of thyrotropin (TSH) concentral to real data shows that pituitary responsiveness to TRH is highest in euthyroidism, reduced in primary hypothyroidism, and lowest in hyperthyroidism.

MeSH terms

  • Feedback
  • Female
  • Humans
  • Hyperthyroidism / metabolism
  • Hypothyroidism / metabolism
  • Male
  • Models, Biological*
  • Pituitary Gland / drug effects*
  • Pituitary Gland, Anterior / drug effects*
  • Thyroid Hormones / blood
  • Thyrotropin / blood
  • Thyrotropin / metabolism*
  • Thyrotropin-Releasing Hormone / pharmacology*
  • Thyroxine / pharmacology
  • Triiodothyronine / pharmacology

Substances

  • Thyroid Hormones
  • Triiodothyronine
  • Thyrotropin-Releasing Hormone
  • Thyrotropin
  • Thyroxine