Cardiovascular teratogenicity of ephedrine in chick embryos

Toxicol Lett. 1985 Dec;29(1):59-63.


The cardiovascular teratogenicity and embryotoxicity of ephedrine was studied in chick embryos treated after 2.5-6 days of incubation (Hamburger-Hamilton developmental stages 17-28). The embryos were examined on day 14. Cardiovascular malformations were observed in 29% (29/101) of treated embryos. Complicated anomalies, such as double-outlet right ventricle (DORV), truncus arteriosus communis (TAC) or overriding aorta with ventricular septal defect (VSD) were seen frequently in embryos exposed to the agent on day 3 of incubation. Malformations were induced by ephedrine at a dose as low as 1 mumol/egg.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cardiovascular Abnormalities
  • Cardiovascular System / drug effects
  • Cardiovascular System / embryology*
  • Chick Embryo
  • Dose-Response Relationship, Drug
  • Ephedrine / toxicity*
  • Teratogens*


  • Teratogens
  • Ephedrine