Hemodialysis clearance of pentobarbital during continuous infusion

Ther Drug Monit. 1985;7(4):485-7. doi: 10.1097/00007691-198512000-00023.


The hemodialysis clearance of pentobarbital during continuous infusion was determined in a 34-year-old man in acute renal failure. Pentobarbital specimens were obtained simultaneously from arterial blood entering and leaving the dialysis machine at five 1-h intervals. The mean hemodialysis clearance of pentobarbital was 22.3 ml/min. Pentobarbital concentration was relatively unaffected throughout the dialysis period, because of the high dose and continuous infusion of a drug with low hepatic intrinsic clearance and a short dialysis period. A large contribution to total body clearance was not evident, and dosage adjustment would have been unwarranted.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / therapy
  • Adult
  • Humans
  • Infusions, Parenteral
  • Male
  • Pentobarbital / administration & dosage
  • Pentobarbital / blood*
  • Renal Dialysis*


  • Pentobarbital