Effect of anti-mu-chain-specific immunosuppression on Chikungunya virus encephalitis of mice

Infect Immun. 1977 Jun;16(3):849-52. doi: 10.1128/iai.16.3.849-852.1977.

Abstract

Mice neonatally immunosuppressed with anti-mu antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antibodies, Anti-Idiotypic / administration & dosage*
  • Antibodies, Viral / biosynthesis
  • Chikungunya virus
  • Encephalitis, Arbovirus / immunology*
  • Encephalitis, Arbovirus / mortality
  • Female
  • Immunoglobulin Heavy Chains*
  • Immunoglobulin mu-Chains*
  • Immunosuppression Therapy*
  • Male
  • Mice
  • Mice, Inbred BALB C

Substances

  • Antibodies, Anti-Idiotypic
  • Antibodies, Viral
  • Immunoglobulin Heavy Chains
  • Immunoglobulin mu-Chains