The International Society for Heart and Lung Transplantation Guidelines for the Management of Pediatric Heart Failure (Update From 2014)

Claire Irving; Estela Azeka; Rachele Adorisio; Elizabeth D Blume; Carmel Bogle; Henry Chubb; Jennifer Conway; Melissa K Cousino; Jonathan Edelson; Katrina Ford; Paula Holinski; Jan Janousek; Ashwin Lal; Teresa Lee; Angela Lorts; Stephanie Nakano; David N Rosenthal; Joseph Rossano; Shelley D Miyamoto

doi:10.1016/j.healun.2025.06.003

The International Society for Heart and Lung Transplantation Guidelines for the Management of Pediatric Heart Failure (Update From 2014)

J Heart Lung Transplant. 2025 Oct;44(10):e21-e71. doi: 10.1016/j.healun.2025.06.003. Epub 2025 Aug 21.

Authors

Claire Irving¹, Estela Azeka², Rachele Adorisio³, Elizabeth D Blume⁴, Carmel Bogle⁵, Henry Chubb⁶, Jennifer Conway⁷, Melissa K Cousino⁸, Jonathan Edelson⁹, Katrina Ford¹⁰, Paula Holinski⁷, Jan Janousek¹¹, Ashwin Lal¹², Teresa Lee¹³, Angela Lorts¹⁴, Stephanie Nakano¹⁵, David N Rosenthal¹⁶, Joseph Rossano¹⁷, Shelley D Miyamoto¹⁸

Affiliations

¹ Department of Pediatrics, Children's Hospital Westmead, Sydney, Australia.
² Department of Pediatric Cardiology and Adults with Congenital Heart Disease, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
³ Feto-Neonatal-Cardiovascular Integrated Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
⁴ Department of Cardiology, Boston Children's Hospital and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
⁵ Department of Pediatrics, University of Maryland, College Park, Maryland.
⁶ Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
⁷ Department of Pediatrics, University of Alberta, Stollery Children's Hospital, Edmonton, Alberta.
⁸ Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
⁹ Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
¹⁰ Department of Pediatrics, Great Ormond Street Hospital, London, UK.
¹¹ Department of Pediatrics, University of Leipzig Heart Center, Strumpellstrasse, Germany.
¹² Department of Pediatrics, University of Utah, Salt Lake City, Utah.
¹³ Department of Pediatrics, Columbia University, New York City, New York.
¹⁴ Cincinnati Children's Hospital, Cincinnati, Ohio.
¹⁵ Department of Pediatrics, University of Colorado Anschutz Medical Campus and Heart Institute, Children's Hospital Colorado, Aurora, Colorado.
¹⁶ Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California. Electronic address: davidnr@stanford.edu.
¹⁷ Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Electronic address: rossanoj@chop.edu.
¹⁸ Department of Pediatrics, University of Colorado Anschutz Medical Campus and Heart Institute, Children's Hospital Colorado, Aurora, Colorado. Electronic address: shelley.miyamoto@childrenscolorado.org.

PMID: 40838915
DOI: 10.1016/j.healun.2025.06.003

Abstract

Pediatric heart failure (HF) secondary to cardiomyopathies, acquired heart disease, and congenital heart disease is associated with significant morbidity and mortality. These guidelines represent an update from the International Society for Heart and Lung Transplantation guidelines for the management of pediatric HF that were published in 2014 and incorporate interval advancements in medical therapies and new approaches in the evaluation and management of children with HF.

Keywords: cardiomyopathy; congenital heart disease; pediatric heart failure; preserved ejection fraction; reduced ejection fraction.

Publication types

Practice Guideline
Review

MeSH terms

Child
Disease Management*
Heart Failure* / diagnosis
Heart Failure* / therapy
Heart Transplantation*
Heart-Lung Transplantation*
Humans
Lung Transplantation*
Societies, Medical*