Abstract
The amount of cytochrome P-450 in microsomes of rat kidney and lungs was 23 and 7%, respectively, of the amount in microsomes of the liver. HPLC profiles of solubilized microsomes showed that there were five or more forms of cytochrome P-450 in microsomes of kidneys and also of lungs of untreated rats. While 3-methylcholanthrene induced a new form of cytochrome P-450 in kidney and lung microsomes, phenobarbital caused no major change in the HPLC profiles of these microsomes.
MeSH terms
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Animals
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Chromatography, High Pressure Liquid
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Cytochrome P-450 Enzyme System / analysis*
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Cytochrome P-450 Enzyme System / biosynthesis
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Cytochrome b Group / analysis
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Cytochrome b Group / biosynthesis
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Cytochromes b5
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Enzyme Induction / drug effects
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In Vitro Techniques
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Isoenzymes / analysis*
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Isoenzymes / biosynthesis
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Kidney / enzymology
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Lung / enzymology
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Male
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Methylcholanthrene / pharmacology
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Microsomes / enzymology*
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Microsomes, Liver / enzymology
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Mixed Function Oxygenases / biosynthesis
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Organ Specificity
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Phenobarbital / pharmacology
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Rats
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Rats, Inbred Strains
Substances
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Cytochrome b Group
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Isoenzymes
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Methylcholanthrene
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Cytochromes b5
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Cytochrome P-450 Enzyme System
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Mixed Function Oxygenases
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Phenobarbital