Movement disorders rounds: Neurophysiological findings in abdominal movements in CASPR2 encephalitis

Talyta Grippe; Tarig Abkur; Yi-Ying Lin; Golsa Shafa; Anuj Rastogi; Robert Chen; Lorraine V Kalia

doi:10.1016/j.parkreldis.2025.107998

Movement disorders rounds: Neurophysiological findings in abdominal movements in CASPR2 encephalitis

Parkinsonism Relat Disord. 2026 Jan:142:107998. doi: 10.1016/j.parkreldis.2025.107998. Epub 2025 Aug 19.

Authors

Talyta Grippe¹, Tarig Abkur², Yi-Ying Lin³, Golsa Shafa⁴, Anuj Rastogi⁴, Robert Chen⁵, Lorraine V Kalia⁵

Affiliations

¹ The Edmond J. Safra Program in Parkinson's Disease, University Health Network, Toronto, Ontario, Canada; Division of Neurology, University of Toronto, Toronto, Ontario, Canada. Electronic address: talyta.cortezgrippe@uhn.ca.
² The Edmond J. Safra Program in Parkinson's Disease, University Health Network, Toronto, Ontario, Canada; Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
³ Krembil Research Institute, University Health Network, Toronto, Canada.
⁴ Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
⁵ The Edmond J. Safra Program in Parkinson's Disease, University Health Network, Toronto, Ontario, Canada; Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, University Health Network, Toronto, Canada.

PMID: 40846620
DOI: 10.1016/j.parkreldis.2025.107998

Abstract

Abdominal movements have been described as a possible unique manifestation of CASPR2-related autoimmune encephalitis. We describe a case of abdominal movements with neurophysiological evaluation showing a mean EMG burst duration of 350 ms and frequency of 1 Hz compatible with myorrhythmia. The case illustrates that awareness of the unique presentations of CASPR2-related autoimmune encephalitis can allow for timely diagnosis and initiation of appropriate treatment.

Keywords: Autoimmune encephalitis; CASPR2; Myorrhythmia; Neurophysiology.

Publication types

Case Reports

MeSH terms

Abdomen* / physiopathology
Electromyography
Encephalitis* / complications
Encephalitis* / diagnosis
Encephalitis* / immunology
Encephalitis* / physiopathology
Humans
Membrane Proteins* / immunology
Movement Disorders* / diagnosis
Movement Disorders* / etiology
Movement Disorders* / physiopathology
Nerve Tissue Proteins* / immunology

Substances

CNTNAP2 protein, human
Membrane Proteins
Nerve Tissue Proteins