Topical estrogen for skin aging: A systematic review of safety and efficacy

Eliana Farkas; Alexandra Goldblatt; Isabella Nehorayan; Rivka Bella Lefkowitz; Lauren Fleshner; Katharine Tepper; Shoshana Marmon

doi:10.1016/j.jaad.2025.08.050

Topical estrogen for skin aging: A systematic review of safety and efficacy

J Am Acad Dermatol. 2026 Jan;94(1):212-215. doi: 10.1016/j.jaad.2025.08.050. Epub 2025 Aug 23.

Authors

Eliana Farkas¹, Alexandra Goldblatt¹, Isabella Nehorayan¹, Rivka Bella Lefkowitz¹, Lauren Fleshner¹, Katharine Tepper¹, Shoshana Marmon²

Affiliations

¹ School of Medicine, New York Medical College, Valhalla, New York.
² School of Medicine, New York Medical College, Valhalla, New York; NYC Health + Hospitals/South Brooklyn Health, Brooklyn, New York. Electronic address: Shoshana.Marmon@nychhc.org.

PMID: 40854497
DOI: 10.1016/j.jaad.2025.08.050

No abstract available

Keywords: MHT; MMP-1; collagen; estradiol; estriol; estrogen; estrone; melasma; menopausal hormone therapy; menopause; perimenopause; phytoestrogen; premarin.