Cardiac and systemic hemodynamic actions of the slow channel calcium blocking agent, KB-944

Gen Pharmacol. 1985;16(6):585-90. doi: 10.1016/0306-3623(85)90147-8.


The effects of KB-944 (10-400 micrograms/kg/min, i.v.), a new slow channel calcium blocking agent, on myocardial oxygen utilization, regional myocardial perfusion and hemodynamics were measured in anesthetized dogs. KB-944 produced significant dose-related increases in coronary blood flow and decreases in heart rate, left ventricular systolic pressure, aortic blood pressure and peripheral vascular resistance. At high doses, peak positive and negative dP/dt were both reduced and left ventricular end diastolic pressure increased. KB-944 reduced arterial-venous oxygen content difference across the heart while significantly increasing coronary blood flow. The pressure rate product, an index of myocardial oxygen consumption, was also reduced. KB-944 produced a uniform and dose-related increase in transmural tissue flow within the left ventricular free wall. These results indicate that KB-944, a new slow channel calcium blocking agent, is a potent peripheral and coronary vasodilator with negative inotropic and chronotropic properties and may be potentially useful in coronary artery disease or hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Benzothiazoles
  • Blood Pressure / drug effects
  • Calcium Channel Blockers / pharmacology*
  • Cardiac Output / drug effects
  • Coronary Circulation / drug effects
  • Diastole / drug effects
  • Dogs
  • Dose-Response Relationship, Drug
  • Female
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Male
  • Myocardium / metabolism*
  • Oxygen Consumption / drug effects*
  • Systole / drug effects
  • Thiazoles / pharmacology*
  • Vascular Resistance / drug effects
  • Vasodilation / drug effects


  • Benzothiazoles
  • Calcium Channel Blockers
  • Thiazoles
  • fosfedil