The information content of phase-known matings for ordering genetic loci

Genet Epidemiol. 1985;2(4):349-61. doi: 10.1002/gepi.1370020404.

Abstract

This analysis evaluates the amount of linkage information that can be obtained for for ordering three loci. The information contents of data collected on three independent pairwise samples of two loci, and data obtained jointly from three loci in a single set of individuals are compared. The level of support of the maximum likelihood order and the interpretation of that support are also examined.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Genes, Dominant
  • Genetic Linkage*
  • Humans
  • Lod Score
  • Models, Genetic
  • Probability